Modelling DTPA therapy following Am contamination in rats - IRSN - Institut de radioprotection et de sûreté nucléaire Accéder directement au contenu
Article Dans Une Revue Radiation and Environmental Biophysics Année : 2023

Modelling DTPA therapy following Am contamination in rats

Résumé

A major challenge in modelling the decorporation of actinides (An), such as americium (Am), with DTPA (diethylenetriaminepentaacetic acid) is the fact that standard biokinetic models become inadequate for assessing radionuclide intake and estimating the resulting dose, as DTPA perturbs the regular biokinetics of the radionuclide. At present, most attempts existing in the literature are empirical and developed mainly for the interpretation of one or a limited number of specific incorporation cases. Recently, several approaches have been presented with the aim of developing a generic model, one of which reported the unperturbed biokinetics of plutonium (Pu), the chelation process and the behaviour of the chelated compound An–DTPA with a single model structure. The aim of the approach described in this present work is the development of a generic model that is able to describe the biokinetics of Am, DTPA and the chelate Am–DTPA simultaneously. Since accidental intakes in humans present many unknowns and large uncertainties, data from controlled studies in animals were used. In these studies, different amounts of DTPA were administered at different times after contamination with known quantities of Am. To account for the enhancement of faecal excretion and reduction in liver retention, DTPA is assumed to chelate Am not only in extracellular fluids, but also in hepatocytes. A good agreement was found between the predictions of the proposed model and the experimental results for urinary and faecal excretion and accumulation and retention in the liver. However, the decorporation from the skeletal compartment could not be reproduced satisfactorily under these simple assumptions.

Domaines

Toxicologie
Fichier principal
Vignette du fichier
Manuscript revised clean Kastl et al 220923 proof 300923.pdf (977.46 Ko) Télécharger le fichier
Supplementary Information rev.pdf (389.23 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Licence : Copyright (Tous droits réservés)
Origine : Fichiers produits par l'(les) auteur(s)
Licence : Copyright (Tous droits réservés)

Dates et versions

irsn-04342934 , version 1 (13-12-2023)

Licence

Copyright (Tous droits réservés)

Identifiants

Citer

Manuel Kastl, Olivier Grémy, Stéphanie Lamart, Augusto Giussani, Wei Bo Li, et al.. Modelling DTPA therapy following Am contamination in rats. Radiation and Environmental Biophysics, 2023, 62 (4), pp.483-495. ⟨10.1007/s00411-023-01046-z⟩. ⟨irsn-04342934⟩
7 Consultations
8 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More